Biosciences research group

Research theme/s:
  • Information on people, projects and publications from our research database
  • Research in the Biosciences Group focuses on the molecular and cell biology of disease. Our specific research interests include microbiology, structural biology, physiology, genomics and disease pathogenesis. Our research is broad and multidisciplinary within and beyond the School of Life and Medical Sciences with national and international collaborators.

    The group is comprised of academics, research staff and full or part-time PhD and MSc by Research students. Research in the biosciences unit is published in high-impact peer-reviewed scientific journals and is presented at national and international conferences.

    Research areas

    • Microbiology of infectious diseases, e.g. Clostridium difficile infection, antimicrobial agent development, and modelling the gut microflora/antimicrobial interactions (Dr Simon Baines)
    • Studying the molecular epidemiology and drug resistance detection in Mycobacterium tuberculosis. Discovery and development of novel antimicrobial agents against Mycobacterium tuberculosis and Gram negative bacteria (Dr Madhu Goyal)
    • Investigation of phage-mediated virulence and antibiotic resistance in Clostridium difficile and development of novel antimicrobial agents or strategies against human and animal pathogens such as Clostridium difficile, Escherichia coli, MRSA, Theileria species, and Mycobacterium bovis (Dr Shan Goh)
    • The role of Extracellular Vesicles in infectious disease; EV-mediated communication within the tumour microenvironment and in metastasis; therapeutic use of stem cell EVs in acute organ injury (Prof. Jameel Inal)
    • Understanding the molecular and cellular mechanisms that underlie human neurodegenerative diseases by using in the nematode Caenorhabditis elegans (Dr Maria Dimitriadi)
    • Genetics, molecular biology and bioinformatics of disease pathogen carrying mosquitoes in relation to their control (Dr Colin Malcolm)
    • Cancer genetics and epigenetics; DNA methylation analysis, chromosomal aberrations and microRNA expression in different malignancies (Dr Maria Braoudaki)
    • Cell polarity in tissue and organ morphogenesis (Dr Caroline Formstone)
    • Kinetics of cell metabolism and signalling underlying hormone secretion in pancreatic islets of Langerhans (Dr Andrei Tarasov)
    • Ehlers Danlos Syndrome (EDS) and associated connective tissue disorders (Dr Philip Sawle)
    • Muscle physiology and muscle diseases (Dr Fang Lou)
    • Computational biochemistry and biophysics applied to viral infections and transmembrane protein-protein interactions (Dr Andreas Kukol)
    • Protein structure determination via NMR spectroscopy; recombinant protein expression and purification in bacterial and yeast expression systems; recombinant protein purification; biophysical analysis of proteins and interactions (Dr Pryank Patel)

    Funding

    Research grants and granted consultancy income have recently been secured from the Wellcome Trust, Royal Society, Procarta Bioscience Ltd, UK India Education Research Initiative (UKIERI), PRODEP Mexico, and the Industrial-Academia Partnerships and Pathways (IAPP) ‘EVEStemInjury’.

    Infrastructure

    Research in the biosciences group is supported by the well-equipped state-of-the-art Science Building that houses cutting-edge research technologies: cell culture and histology facilities, molecular biology laboratories, fermentation equipment for medical microbiology and biotechnology research, anaerobic microbiology facilities, confocal imaging and C. elegans microscopy, fluorescence spectroscopy, FTIR spectroscopy, NMR, access to the UH high performance computer cluster, MALDI-TOF MS and Nanosight Tracking Analysis (NTA, LM10) for Extracellular Vesicle characterisation.

    Research degrees and post-doctoral fellowships

    Applications are invited from candidates with good first degrees in biosciences, chemistry, bio-physics, genetics, neuroscience or other relevant disciplines to join projects as research students. Projects are available for PhD and MSc by Research students in the areas mentioned above (but not limited to). In addition, we welcome Visiting Researchers and Postdoctoral Fellowships in the research areas above. We will gladly support and assist with fellowship applications to national and international research councils or charities.

    To learn more about the research degree programmes offered in biosciences please visit the Doctoral College page.

    We recommend that you discuss your proposed research with a member of academic staff of the Biosciences Research Group before submitting your application. Please name the staff member when submitting your application.

    For informal enquiries, please contact Dr Yongju Huang, Biological and Environmental Sciences Research Tutor.

    Download your application form here. Application forms should be returned to Mrs Elizabeth Day, Research degrees administrator.

    Email Dr Maria Dimitriadi for any enquiries about this research group.