Delivered by Dr. Bill Broadhurst, Department of Biochemistry, University of Cambridge
I will provide a brief introduction to protein dynamics on different timescales and ways of quantifying these processes, with a particular focus on NMR spectroscopy. I will then discuss an application to the conformational plasticity of ligand-bound ternary complexes of the beta1-adrenergic receptor, a model G-protein coupled receptor (Nature Communications (2020) 11, 669). After that I will describe some of my work on the dynamics of acyl carrier protein domains in modular polyketide synthase multienzyme complexes (Biochemical J (2016) 473, 1097-1110; Scientific Reports (2019) 9, 2325; Chemical Comm (2017) 53, 11457-11460).