The Cell Models and Biotechnology group focuses on the application of the life sciences to the fields of engineering, medicine and technology - with particular emphasis on their use in regenerative medicine and drug formulation, manufacture and delivery.
The group primarily develops accurate and biosensitive, in-vitro-in vivo-like, models of human tissues and organs through the use of cells, materials and growth factors to understand the underlying biological mechanisms involved. Specialist expertise within the group centres on the development of alternative models of the skin, eye, lung and liver. In addition, the group also considers the exploitation of novel drug delivery vehicles to enhance the therapeutic efficacy of a drug, as well as innovative techniques to aid the modulation of the biological characteristics of the cells themselves.
Ultimately, the development of these more accurate and predictive cell models play a pivotal role in the translation and assessment of drugs for safety and use in clinical practice.
The Cell Models and Biotechnology group focuses on the in vitro model design, characterisation and validation of tissues and/or organs of interest. In addition, exploitation of these engineered models are used to assess toxicity and efficacy characteristics of novel compounds or therapeutics. Specific research interests include: