Impact of CLiCIR research
We have recently started to document examples of CLiCIR research which have impacted on NHS policy and service delivery. Here is a summary of what we have to date:
End of Life Care in renal disease
Original CLiCIR supported papers
Chandna, Schultz, Lawrence, Greenwood, and Farrington (1999). Is there a rationale for rationing chronic dialysis? A hospital-based cohort study of factors affecting survival and morbidity. BMJ, 318, p217-223. Cited more than 125 times.
Smith C, Da Silva-Gane M, Chandna S, Warwicker P, Greenwood R, Farrington K. (2003). Choosing not to dialyse: evaluation of planned non-dialytic management in a cohort of patients with end-stage renal failure. Nephron Clin. Pract.; 95: c40-c46.
Shahid M. Chandna, S.M., Da Silva-Gane, M., Marshall, C., Warwicker, P., Greenwood, R.N., Farrington, K. (2011). Survival of elderly patients with stage 5 CKD: comparison of conservative management and renal replacement therapy. Nephrol. Dial. Transplant. 26: 1608–1614.
Impact:
These papers are cited in:
NHS Guidelines
Planning for End-of-Life Care in Dialysis Patients: Attitudes and Perceptions Maria Da Silva-Gane, Prof Ken Farrington
More information on this project on UK Clinical Research Network : Portfolio Database
National Service Framework for Renal Services (PDF - 0.18 Mb)
Renal Association Guidelines
More information on Guidelines in Renal Replacement Therapy
Kidney Research UK – “Choosing not to start dialysis” (PDF - 0.09 Mb)
Work disability, and early intervention in rheumatoid arthritis
Original CLiCIR supported papers
Young, A., Dixey, J., Kulinskaya,E. et al (2002) Which patients stop working because of rheumatoid arthritis? Results of five years' follow up in 732 patients from the Early RA Study (ERAS). Ann Rheum Dis 2002; 61:335-340 doi:10.1136/ard.61.4.335. Cited 136.
Young, A., Koduri, G., Batley, M., Kulinskaya, E., Gough, A.,Norton, S., Dixey, J. on behalf of the Early Rheumatoid Arthritis Study (ERAS) group (2006) Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology, 46(2), 350-357. Doi: 10.1093/rheumatology/kel253. Cited 86.
Impact
NICE guideline on rheumatoid arthritis
Standards of Care for People with Inflammatory Arthritis published by the Arthritis and Musculoskeletal Alliance (ARMA) [link]
House of Commons Public Accounts Committee - Tenth Report - Services for people with rheumatoid arthritis [link]
Early detection of those at risk of psychosis and early intervention in psychosis services
Original CLiCIR supported papers
Done DJ, Johnstone EC, Frith CD, Golding J, Shepherd PM, Crow TJ (1991). Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British perinatal mortality survey sample. British Medical Journal 302,1576-1580.
Done DJ, Crow TJ, Johnstone EC, Sacker A (1994) Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. British Medical Journal,309,699-703.
Schulz,J., Sundin,J., Leask,S., Done,D.J. Evidence for a non-linear relationship between general intelligence in childhood and risk of schizophrenia in adult life – findings of a birth cohort study. British Journal of Psychiatry, under review.
Done DJ,Leinonen E, Sacker A, et al (1998) Linguistic performance in pre-schizophrenic children: evidence for normal syntactic ability. British Journal of Psychiatry 172, 130-5.
Sacker A, Done DJ, Crow TJ, (1996) Antecedents of schizophrenia and affective illness: A meta-anlaysis of obstetric complications in children born to schizophrenic parents. Psychological Medicine,26,279-287
Impact
Done et al 1991 and 1994 have been cited over 300 times each and contributed to the understanding that adult onset schizophrenia was a disorder which developed many years before symptom onset and referral to psychiatric services.
This contributed to the development of EIPS in 2004, a nationwide early intervention service designed to pick up young people at risk of developing psychosis or at an early stage of psychosis.